HCID 14750969, compound → 2-Aminotetralin

Participants

Reaction Steps

Following the procedure described in Example 27, but starting from 2-acetyl-7-(2,3-epoxypropoxy)benzofuran (23.2 g), obtained from 2-acetyl-7- hydroxybenzofuran and epichlorohydrin according to the teaching of Belgian Patent 783,440, and 2-aminotetralin (14.81 g) in ethanol (120 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-acetylbenzofuran-7-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 24 wherein Z is acetyl and the chain bridges position 4 of the Ar group to position 2 of the tetralin moiety).

Provenance & Evidence