N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-[[4-(4,5,6,7-tetrahydrobenzofuran-2-yl)]phenoxy]propanamine hydrochloride → 2-Aminotetralin

Beteiligte Stoffe

Reaktionsschritte

Following the procedure of Example 27, but starting from 4-(4,5,6,7-tetrahydrobenzofuran-2-yl)-1-(2,3-epoxypropoxy)benzene (27 g), obtained according to the teaching of U.S. Pat. No. 3,894,058, and 2-aminotetralin (14.85 g) in ethanol (150 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-[[4-(4,5,6,7-tetrahydrobenzofuran-2-yl)]phenoxy]propanamine hydrochloride is obtained ((i): R=H, Ar=radical 31 wherein Z is H, and the chain is attached to position 2 of the tetralin moiety).

Herkunft & Nachweise