N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(3-methyl-1,2-benzisoxazol-4-yloxy)propanamine hydrochloride → 2-Aminotetralin

HRID 1656630Notes

Reaction equation

HRID 1656630 reaction equation
O1CC1COC1C2C(C)=NOC=2C=CC=1.Cl.[CH2:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][CH2:19][CH:18]1[NH:27]CC(O)COC1C2C(C)=NOC=2C=CC=1>C(O)C>[NH2:27][CH:18]1[CH2:19][CH2:20][C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:17]1

Participants

4

Reactant 2

HCID 14751001N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(3-methyl-1,2-benzisoxazol-4-yloxy)propanamine hydrochlorideHCID 197882843-Methyl-4-[(oxiran-2-yl)methoxy]-1,2-benzoxazole

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure of Example 27, but starting from 4-(2,3-epoxypropoxy)-3-methyl-1,2-benzisoxazole (20.5 g) (DE-2,711,382) and 2-aminotetralin (14.82 g) in absolute ethanol (150 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(3-methyl-1,2-benzisoxazol-4-yloxy)propanamine hydrochloride is obtained ((i), R=H, Ar=radical 59, and the chain is attached to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-8e4fc8b5c2254ff9976d193ace428ba0
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

Loading…