反应详情

Following the procedure of Example 27, but starting from 4-(2,3-epoxypropoxy)-3-methyl-1,2-benzisoxazole (20.5 g) (DE-2,711,382) and 2-aminotetralin (14.82 g) in absolute ethanol (150 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(3-methyl-1,2-benzisoxazol-4-yloxy)propanamine hydrochloride is obtained ((i), R=H, Ar=radical 59, and the chain is attached to position 2 of the tetralin moiety).