HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(3-methyl-1,2-benzisoxazol-4-yloxy)propanamine hydrochloride → 2-Aminotetralin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(3-methyl-1,2-benzisoxazol-4-yloxy)propanamine hydrochloride | HCID 14751001 | — |
| Reactant | 3-Methyl-4-[(oxiran-2-yl)methoxy]-1,2-benzoxazole | HCID 19788284 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Aminotetralin | HCID 34677 | — |
Reaction Steps
Following the procedure of Example 27, but starting from 4-(2,3-epoxypropoxy)-3-methyl-1,2-benzisoxazole (20.5 g) (DE-2,711,382) and 2-aminotetralin (14.82 g) in absolute ethanol (150 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(3-methyl-1,2-benzisoxazol-4-yloxy)propanamine hydrochloride is obtained ((i), R=H, Ar=radical 59, and the chain is attached to position 2 of the tetralin moiety).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05254595 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-8e4fc8b5c2254ff9976d193ace428ba0 |
| Source note | uspto-grants-1993_10 |