2-({2-[(Prop-2-yn-1-yl)oxy]phenoxy}methyl)oxirane → 2-Aminotetralin

HRID 1656638Notes

Reaction equation

HRID 1656638 reaction equation
C(OC1C=CC=CC=1OCC1OC1)C#C.Cl.[CH2:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][CH2:19][CH:18]1[NH:27]CC(O)CC1C=CC=CC=1OCC#C>C(O)C>[NH2:27][CH:18]1[CH2:19][CH2:20][C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:17]1

Participants

4

Reactant 2

HCID 128126532-({2-[(Prop-2-yn-1-yl)oxy]phenoxy}methyl)oxiraneHCID 19788299HCID 19788299, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure of Example 27, but starting from 2-propargyloxy-l-(2,3-epoxypropoxy)benzene (2.04 g) and 2-aminotetralin in absolute ethanol (30 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-propargyloxyphenyl)propanamine hydrochloride is obtained, m.p. 129°-130° C. (Ex. 85).

Sources & evidence

ORD record
ord-6d174fa497ef468097e0af2afb480e80
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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