HCID 15676488, compound → HCID 15676489, compound

HRID 1656678Notes

Reaction equation

HRID 1656678 reaction equation
Cl[C:2]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:3]=1[NH:4][C:5](=[S:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.N1(C2CCCCCCCCCC2)CCCCCCCCCN1>CN(C)C=O>[CH3:17][C:16]1[C:2]2[S:12][C:5]([C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)=[N:4][C:3]=2[CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 15676488HCID 15676488, compoundHCID 57346892Diazabicycloundecane

Product 1

HCID 15676489HCID 15676489, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

91.6 g (0.35 mol) of the compound from Example VI in 1 l of dimethylformamide were boiled under reflux with 64 g (0.42 mol) of diazabicycloundecane for 3 h. The mixture was concentrated, the residue was taken up in methylene chloride/water, and the solution was rendered weakly acidic, washed with water, dried and concentrated. Yield: 70 g (89% of theory) M.p.: 53°-54° C.

Workup

  1. concentrationThe mixture was concentrated
  2. washwashed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-fcc315f7825d4996ad9bd468704091c5
Source dataset
uspto-grants-1993_10
Patent number
US05254692

Reaction notes

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