HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylmorpholine N-oxide monohydrate → Methyl alpha-(2-formylphenyl)-beta-methoxyacrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylmorpholine N-oxide monohydrate | HCID 2724197 | — |
| Reactant | Methyl 2-[2-(bromomethyl)phenyl]-3-methoxyprop-2-enoate | HCID 53395349 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Methyl alpha-(2-formylphenyl)-beta-methoxyacrylate | HCID 53811047 | 67.2% |
Reaction Steps
35.5 g (0.125 mol) of methyl alpha-(2-bromomethylphenyl)-β-methoxyacrylate are dissolved in 500 ml of CCl4. 43.4 g (0.321 mol) of methylmorpholine N-oxide monohydrate are added, and the mixture is refluxed for 20 hours. The solid is filtered of f and the CCl4 phase is washed with water, with 2 N hydrochloric acid and again with water, dried and concentrated. 18.5 g (67%) of product are obtained as a reddish brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05254717 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-146f12103baa42ee9b84cc65d41ab655 |
| Source note | uspto-grants-1993_10 |