Acetic Acid → HCID 20083120, compound

HRID 1656744Notes

Reaction equation

HRID 1656744 reaction equation
[Cl:1][C:2]1[C:3]([F:21])=[C:4]2[C:9]3=[C:10]([C:12](=[O:19])[C:13]([C:15]([O:17]C)=[O:16])=[CH:14][N:8]3[N:7]([CH3:20])[CH2:6][CH2:5]2)[CH:11]=1.Cl.C(O)(=O)C>O>[Cl:1][C:2]1[C:3]([F:21])=[C:4]2[C:9]3=[C:10]([C:12](=[O:19])[C:13]([C:15]([OH:17])=[O:16])=[CH:14][N:8]3[N:7]([CH3:20])[CH2:6][CH2:5]2)[CH:11]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 20083093HCID 20083093, compound

Product 1

HCID 20083120HCID 20083120, compoundYield 81.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 600 mg (1.9 mmol) of the compound (133) obtained in Example 25, 5 ml of concentrated hydrochloric acid and 20 ml of acetic acid were added, and the solution was heated at reflux for 2 hours. After air-cooling, 20 ml of water was added to the solution, and solids were filtered off and washed with ethanol and ether in this order to obtain 461 mg of the subject compound (134) in a 80% yield.

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 2 hours
  3. temperatureAfter air-cooling
  4. filtrationwere filtered off
  5. washwashed with ethanol and ether in this order

Sources & evidence

ORD record
ord-529dc38516d94057a188df75f8909de0
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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