Hydrochloric Acid → HCID 20083135, compound

HRID 1656748Notes

Reaction equation

HRID 1656748 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:12](=[O:19])[C:13]([C:15]([O:17]C)=[O:16])=[CH:14][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH3:20].Cl>C(O)(=O)C>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:12](=[O:19])[C:13]([C:15]([OH:17])=[O:16])=[CH:14][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20083109HCID 20083109, compound

Product 1

HCID 20083135HCID 20083135, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 370 mg (1.3 mmol) of the compound (145) obtained in Example 30, 2 ml of concentrated hydrochloric acid and 10 ml of acetic acid were added, and the solution was heated at reflux for 2 hours. The solvent was removed by distillation. Crystals were dispersed in ethanol and filtered and washed with ethanol and ether in this order to obtain 270 mg of the subject compound (146) in a 77% yield.

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 2 hours
  3. customThe solvent was removed by distillation
  4. additionCrystals were dispersed in ethanol
  5. filtrationfiltered
  6. washwashed with ethanol and ether in this order

Sources & evidence

ORD record
ord-ece4b91676b7419b8696d9c73fceeea7
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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