Trifluoroacetic acid → HCID 19788679, compound

HRID 1656758Notes

Reaction equation

HRID 1656758 reaction equation
[F:1][C:2]1[C:3]([CH:22]([C:30]#[N:31])C(OC(C)(C)C)=O)=[C:4]2[C:9]3=[C:10]([C:12](=[O:20])[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:14][N:8]3[N:7]([CH3:21])[CH2:6][CH2:5]2)[CH:11]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[C:30]([CH2:22][C:3]1[C:2]([F:1])=[CH:11][C:10]2[C:12](=[O:20])[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:14][N:8]3[C:9]=2[C:4]=1[CH2:5][CH2:6][N:7]3[CH3:21])#[N:31]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 20083099HCID 20083099, compound

Product 1

HCID 19788679HCID 19788679, compoundYield 33.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.60 g of the compound (162) obtained in Example 39 (2) was added to 20 ml of methylene chloride, and 6 ml of trifluoroacetic acid was added to the solution. The solution was stirred for 1.5 hours. 4 ml of trifluoroacetic acid was added to the solution, and the solution was stirred overnight. The solvent was removed by distillation, and the residue was crystallized from ethyl ether. Crystals were filtered off to obtain 410 mg of the subject compound (165).

Workup

  1. additionwas added to the solution
  2. stirringthe solution was stirred overnight
  3. customThe solvent was removed by distillation
  4. customthe residue was crystallized from ethyl ether
  5. filtrationCrystals were filtered off

Sources & evidence

ORD record
ord-d6dc04a1394145d2bfa04c1871f21532
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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