Hydrochloric Acid → HCID 20083102, compound

HRID 1656759Notes

Reaction equation

HRID 1656759 reaction equation
F[C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:19])[C:14]([C:16]([OH:18])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH3:20].[OH-:21].[K+].Cl>>[F:12][C:11]1[C:2]([OH:21])=[C:3]2[C:8]3=[C:9]([C:13](=[O:19])[C:14]([C:16]([OH:18])=[O:17])=[CH:15][N:7]3[N:6]([CH3:20])[CH2:5][CH2:4]2)[CH:10]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 10356293HCID 10356293, compound

Product 1

HCID 20083102HCID 20083102, compound

Procedure

2.78 g of the compound (8) obtained in Example 3 was added to 10 ml of aqueous 30% potassium hydroxide solution, and the solution was heated at reflux for 6 hours. After air-cooling, the solution was acidified with 6N hydrochloric acid, and the deposited solids were filtered off and washed with water, ethanol and isopropyl ether in this order to obtain 2.60 g of the subject compound (166).

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 6 hours
  3. temperatureAfter air-cooling
  4. filtrationthe deposited solids were filtered off
  5. washwashed with water, ethanol and isopropyl ether in this order

Sources & evidence

ORD record
ord-ba74317297c64067a0cd4801602cb4e5
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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