Methanol → HCID 20083159, compound

HRID 1656768Notes

Reaction equation

HRID 1656768 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH2:22][OH:23].[CH2:24](N(S(F)(F)F)CC)C.CO>O1CCCC1>[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH2:22][O:23][CH3:24]

Participants

5

Reactant 3

HCID 887MethanolHCID 123472(Diethylamino)sulfur trifluorideHCID 20083158HCID 20083158, compound

Product 1

HCID 20083159HCID 20083159, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

65 mg of the compound (177) obtained in Example 54 was suspended in 5 ml of tetrahydrofuran, and 270 μl of diethylaminosulfurtrifluoride was added to the solution. The solution was stirred for 4 hours, and 1 ml of methanol was added to the solution. The deposited solid matter was filtered off and washed with ether to obtain 34 mg of the subject compound (180).

Workup

  1. filtrationThe deposited solid matter was filtered off
  2. washwashed with ether

Sources & evidence

ORD record
ord-0b59a0d3697f4fd69593aba2b3f00dc7
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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