Acetic Acid → HCID 20083130, compound

HRID 1656782Notes

Reaction equation

HRID 1656782 reaction equation
[F:1][C:2]1[C:11]([F:12])=[C:10]([NH2:13])[C:9]2[C:14](=[O:22])[C:15]([C:17]([O:19]CC)=[O:18])=[CH:16][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH3:23].C(O)(=O)C.Cl>O>[NH2:13][C:10]1[C:9]2[C:14](=[O:22])[C:15]([C:17]([OH:19])=[O:18])=[CH:16][N:7]3[C:8]=2[C:3]([CH2:4][CH2:5][N:6]3[CH3:23])=[C:2]([F:1])[C:11]=1[F:12]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 21733326HCID 21733326, compound

Product 1

HCID 20083130HCID 20083130, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

20 mg of the compound (201) obtained in Example 72 was added to 0.4 ml of acetic acid and 0.1 ml of 12 N hydrochloric acid, and the solution was heated at 100° C. for 2 hours. After air-cooling, the water was added to the reaction solution, and the deposited solids were filtered off and washed consecutively with water, ethanol and ether to obtain 13 mg of the subject compound (202) in a 72% yield.

Workup

  1. temperatureAfter air-cooling
  2. filtrationthe deposited solids were filtered off
  3. washwashed consecutively with water, ethanol and ether

Sources & evidence

ORD record
ord-99b7b39e8ab34aa69fa7e37f10a2c979
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

Loading…