Sodium Hydroxide → HCID 131718233, compound

Participants

Reaction Conditions

Reaction Steps

100 g L(+)-lactic acid are dissolved in 250 ml water whilst stirring at 20° C. (1.11 mol.) Under constant stirring 226.8 g (1.1 mol) S(+)-ibuprofen are introduced, the solution gradually being heated (within 10 minutes) to 35°-40 ° C. The pH of the solution should not exceed 6.0 when using a 0.001M NaHPO4 /NaH2PO4 buffer. With a simple aqueous solution (pH 5.5-6.0) it should be ensured that the pH does not drop below 4.0, this possibly making necessary a titration back to the original pH 5.5-6.0 again with diluted NaOH. The temperature of 35°-40° C. should be strictly observed to ensure that no segregation occurs. After about 30 minutes a clear solution is obtained which is cooled to 0°-4° C., whereupon the crystals of the complex form.

Provenance & Evidence