Sodium Hydroxide → HCID 131718233, compound

HRID 1656799Notes

Reaction equation

HRID 1656799 reaction equation
[C:1]([OH:6])(=[O:5])[C@H:2]([CH3:4])[OH:3].[CH3:7][C@H:8]([C:19]([OH:21])=[O:20])[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([CH3:18])[CH3:17])=[CH:11][CH:10]=1.[OH-].[Na+]>O>[CH3:7][C@H:8]([C:19]([OH:21])=[O:20])[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([CH3:17])[CH3:18])=[CH:11][CH:10]=1.[C:1]([OH:6])(=[O:5])[C@H:2]([CH3:4])[OH:3]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 39912DexibuprofenHCID 107689L-Lactic Acid

Product 1

HCID 131718233HCID 131718233, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
20 °C

Procedure

100 g L(+)-lactic acid are dissolved in 250 ml water whilst stirring at 20° C. (1.11 mol.) Under constant stirring 226.8 g (1.1 mol) S(+)-ibuprofen are introduced, the solution gradually being heated (within 10 minutes) to 35°-40 ° C. The pH of the solution should not exceed 6.0 when using a 0.001M NaHPO4 /NaH2PO4 buffer. With a simple aqueous solution (pH 5.5-6.0) it should be ensured that the pH does not drop below 4.0, this possibly making necessary a titration back to the original pH 5.5-6.0 again with diluted NaOH. The temperature of 35°-40° C. should be strictly observed to ensure that no segregation occurs. After about 30 minutes a clear solution is obtained which is cooled to 0°-4° C., whereupon the crystals of the complex form.

Workup

  1. additionare introduced
  2. temperaturethe solution gradually being heated (within 10 minutes) to 35°-40 ° C
  3. customThe temperature of 35°-40° C.
  4. customAfter about 30 minutes a clear solution is obtained which
  5. temperatureis cooled to 0°-4° C., whereupon the crystals of the complex form

Sources & evidence

ORD record
ord-f58bf37943a24dfe8e015c702293ff0a
Source dataset
uspto-grants-1993_10
Patent number
US05254728

Reaction notes

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