Formaldehyde → HCID 86747326, compound

Participants

Reaction Steps

0.22 g of 1-(6-chloro-3-pyridylmethyl)-2-nitromethyleneimidazolidine, 0.08 g of 37% formaldehyde aqueous solution and 0.1 g of ethyl thioglycolate were added to 5 ml of ethanol, and were reacted under reflux for 3 hours. After completing the reaction, ethanol was distilled off under reduced pressure, and a small amount of ethyl acetate was added to the residue thus obtained to filter the insoluble materials out, thus obtaining 0.25 g of the aimed product (Compound No. 1) having a melting point of from 122.8° to 124.3° C. wherein i is 1, can be obtained, and when the oxidizing agent is used in a molar amount of two times as large as the compound having the formula (I-1), the compound having the formula (I-2) wherein i is 2, can be obtained. (iii) When Z is an alkyl group or an acyl group: ##STR13## (wherein X, Y and j are as defined above; Z' is an alkyl group or an acyl group; and Q is a halogen atom or an acid residue).

Provenance & Evidence