反应详情

温度

190 °C

30 g of 1-chloro-2-methyl-3-prop-2-enylbenzene are dissolved in 150 ml of N-methylpyrrolidone, and 25 g of copper(I) cyanide are added. The reaction mixture is heated at 190° C. for 30 hours while stirring. After the mixture has been cooled to 20° C., 125 ml of ethylenediamine and 300 ml of water are added. Stirring is then carried out for 1 hour at 50° C. and for 14 hours at 20° C. Working up is effected by extracting with diethyl ether, washing the organic phase and drying over sodium sulfate, removing the drying agent and distilling off the organic solvent. 24.5 g of crude product are obtained. After chromatography (silica gel/toluene), 14.4 g of pure 1-cyano-2-mehtyl-3-prop-2-enylbenzene are isolated.

1. temperatureAfter the mixture has been cooled to 20° C.
2. stirringStirring
3. extractionby extracting with diethyl ether
4. washwashing the organic phase
5. dry with materialdrying over sodium sulfate
6. customremoving the drying agent
7. distillationdistilling off the organic solvent
8. custom24.5 g of crude product are obtained