Hydrochloric Acid → HCID 18954726, compound

HRID 1656947Notes

Reaction equation

HRID 1656947 reaction equation
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)=[CH:8][N:9]=1)(=O)C.Cl.[OH-].[Na+]>C(O)(=O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)=[CH:8][N:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15729149HCID 15729149, compound

Product 1

HCID 18954726HCID 18954726, compoundYield 81.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2-acetylamino-5-(4-aminophenylthio)thiazole (2.5 g) in a mixture of acetic acid (20 ml) and 6N-aqueous hydrochloric acid (5 ml) was refluxed for 4 hours with stirring. The reaction mixture was poured into ice-water and the solution was adjusted to pH 10 using 1N-aqueous sodium hydroxide with stirring under ice cooling. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-amino-5-(4-aminophenylthio)thiazole (1.70 g, yield: 81.5%).

Workup

  1. temperaturewas refluxed for 4 hours
  2. stirringwith stirring under ice cooling
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-6ac500995a7b4ee8b13922b1cc89d9dc
Source dataset
uspto-grants-1993_10
Patent number
US05256675

Reaction notes

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