Hydrochloric Acid → HCID 15729161, compound

HRID 1656962Notes

Reaction equation

HRID 1656962 reaction equation
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[N:12]([CH3:16])[CH:13]=[CH:14][N:15]=2)=[CH:8][N:9]=1)(=O)C.Cl>C(O)(=O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[N:12]([CH3:16])[CH:13]=[CH:14][N:15]=2)=[CH:8][N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15729160HCID 15729160, compound

Product 1

HCID 15729161HCID 15729161, compoundYield 83.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2-acetylamino-5-(1-methylimidazol-2-ylthio)thiazole (7.0 g) in a mixture of acetic acid (100 ml) and aqueous 6N-hydrochloric acid (20 ml) was refluxed for 3.5 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was adjusted to pH 8 using aqueous sodium bicarbonate under ice cooling. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-amino-5-(1-methylimidazol-2-ylthio)thiazole (4.9 g, yield: 83.9%). mp: 180°-190° C. (dec.) IR (Nujol): 3300, 3150, 1620, 1530, 1280, 1220 cm-1

Workup

  1. temperaturewas refluxed for 3.5 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-5fa7ea58a6104b1ca3d449fa43df4c35
Source dataset
uspto-grants-1993_10
Patent number
US05256675

Reaction notes

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