反应详情

A mixture of 2-formylamino-4-(4-pyridylthiomethyl)thiazole (1.6 g) and N-chlorosuccinimide (1.5 g) in acetic acid (25 ml) was heated at 40°-50° C. for 5 hours with stirring and then the mixture was allowed to stand at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure and the residue was triturated with aqueous sodium bicarbonate. The precipitates were collected by filtration washed with water and dried in vacuo to give 5-chloro-2-formylamino-4-(4-pyridylthiomethyl)thiazole (0.85 g, yield: 46.8%). mp: 200°-203° C. (dec.) IR (Nujol): 1680, 1665, 1587, 1300 cm-1

1. temperaturewas heated at 40°-50° C. for 5 hours
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe residue was triturated with aqueous sodium bicarbonate
4. filtrationThe precipitates were collected by filtration
5. washwashed with water
6. customdried in vacuo