反应详情

To a stirred mixture of 465 parts of 1,3-difluorobenzene and 133.3 parts of aluminum trichloride was added dropwise a mixture of 110.1 parts of 4-chloro-3-nitro-benzoyl chloride and 116 parts of aluminum trichloride at 70° C. After stirring for 2 hours at reflux temperature, the reaction mixture was poured into ice-water. There were added 127 parts of hydrochloric acid and the product was extracted with trichloromethane. The extract was dried, filtered and evaporated. The residue was stirred in 2,2'-oxybispropane. The product was filtered off and dried, yielding 130 parts (87.4%) of (4-chloro-3-nitrophenyl) (2,4-difluorophenyl)methanone; mp. 90.5° C.(interm. 1).

1. additionwas added dropwise
2. temperatureat reflux temperature
3. extractionthe product was extracted with trichloromethane
4. customThe extract was dried
5. filtrationfiltered
6. customevaporated
7. stirringThe residue was stirred in 2,2'-oxybispropane
8. filtrationThe product was filtered off
9. customdried