Piperidine → HCID 67853764, compound

HRID 1657086Notes

Reaction equation

[ClH:1].[CH3:2][N:3]([CH2:5][CH:6]1[C:20](=[O:21])[C:10]2[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:12][O:13][C:9]=2[CH2:8][CH2:7]1)[CH3:4].[NH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[OH2:13].[ClH:1].[N:3]1([CH2:5][CH:6]2[C:20](=[O:21])[C:10]3[C:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)=[N:12][O:13][C:9]=3[CH2:8][CH2:7]2)[CH2:2][CH2:25][CH2:24][CH2:23][CH2:4]1.[N:22]1([CH2:5][CH:6]2[C:20](=[O:21])[C:10]3[C:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)=[N:12][O:13][C:9]=3[CH2:8][CH2:7]2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1.[ClH:1]

Participants

Reactant 2

HCID 8082Piperidine

HCID 19786539HCID 19786539, compound

Product 1

HCID 67853764HCID 67853764, compound

Procedure

6,7-Dihydro-5-dimethylaminomethyl-3-phenyl- 1,2-benzisoxazol-4(5H)-one hydrochloride (0.80 g) was warmed with 5 ml of piperidine (4.31 g) at 90° C. for 20 minutes. The excess piperidine was removed in vacuo and the hydrochloride was formed in ethereal HCl to give 0.95 g of 6,7-dihydro-5-(1-piperidinylmethyl)-3-phenyl-1,2-benzisoxazol-4(5H)-one hydrochloride hemihydrate, m.p. 182°-1830° C.

Workup

customThe excess piperidine was removed in vacuo

Sources & evidence

ORD record: ord-cd412f8cbd6a463d93f563733b9540f5
Source dataset: uspto-grants-1993_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05256672

Reaction notes

Loading…