反应详情

温度

90 °C

To 5-chloro-2-nitrobenzamide (2.0 g) (prepared according to the procedure described in Example 1, Part A) was added 50 mL of glacial acetic acid. This solution was heated to 90° C. and iron powder (2.8 g) was added in small portions over 15 minutes. When addition was complete the reaction mixture was stirred at 90°-100° C. After 2 hours the reaction was cooled to room temperature and was evaporated to dryness. The resulting residue was partitioned between ethyl acetate and aqueous sodium carbonate. This brown slurry was filtered and the ethyl acetate layer was recovered and washed with brine, dried over anhydrous magnesium sulfate, filtered and evaporated to dryness to yield 1.7 g (100%) of a buff powder: 1H NMR (DMSO-d6, 300 MHz) δ 7.83 (bs, 1H), 7.59 (d, 1H), 7.17 (bs, 1H), 7.14 (dd, 1H), 6.70 (m, 3H).

1. additionWhen addition
2. temperatureAfter 2 hours the reaction was cooled to room temperature
3. customwas evaporated to dryness
4. customThe resulting residue was partitioned between ethyl acetate and aqueous sodium carbonate
5. filtrationThis brown slurry was filtered
6. customthe ethyl acetate layer was recovered
7. washwashed with brine
8. dry with materialdried over anhydrous magnesium sulfate
9. filtrationfiltered
10. customevaporated to dryness
11. customto yield 1.7 g (100%) of a buff powder