Propanal → HCID 13359377, compound

HRID 1657214Notes

Reaction equation

HRID 1657214 reaction equation
[CH:1](=[O:4])CC.[C:5]([O:9][CH3:10])(=[O:8])[CH:6]=O.N([CH2:13][C:14](O)=O)C>CO>[CH:1](/[C:6](=[CH:13]\[CH3:14])/[C:5]([O:9][CH3:10])=[O:8])=[O:4]

Participants

5

Reactant 3

HCID 527PropanalHCID 1088SarcosineHCID 70205Acetic acid, 2-oxo-, methyl ester

Product 1

HCID 13359377HCID 13359377, compoundYield 16.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

174 g (3 mol) of propionaldehyde were added within 1 h to a mixture of 264 g (3 mol) of methyl glyoxylate, 96 g of methanol and 2.7 g (0.03 mol) of sarcosine at 80° C. After the addition was complete the reaction mixture was stirred at 80° C. for 1 h and then distilled under a pressure of 1 mbar in a thin-film evaporator. 417 g of distillate which contained 50.8% methyl 2-hydroxy-3-formylbutanoate and 16.4% methyl formylcrotonate were obtained.

Workup

  1. additionAfter the addition
  2. distillationdistilled under a pressure of 1 mbar in a thin-film evaporator

Sources & evidence

ORD record
ord-450060906c624f769024723767ec8278
Source dataset
uspto-grants-1993_10
Patent number
US05256813

Reaction notes

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