Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propanal | HCID 527 | — |
| Reactant | Sarcosine | HCID 1088 | — |
| Reactant | Acetic acid, 2-oxo-, methyl ester | HCID 70205 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 13359377 | HCID 13359377 | 16.4% |
Reaction Steps
174 g (3 mol) of propionaldehyde were added within 1 h to a mixture of 264 g (3 mol) of methyl glyoxylate, 96 g of methanol and 2.7 g (0.03 mol) of sarcosine at 80° C. After the addition was complete the reaction mixture was stirred at 80° C. for 1 h and then distilled under a pressure of 1 mbar in a thin-film evaporator. 417 g of distillate which contained 50.8% methyl 2-hydroxy-3-formylbutanoate and 16.4% methyl formylcrotonate were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05256813 |
|---|
| Source dataset | uspto-grants-1993_10 |
|---|
| ORD ID | ord-450060906c624f769024723767ec8278 |
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| Source note | uspto-grants-1993_10 |
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