Water → 2,2-Dimethylpropionic acid 1-[3-(6,7-difluoro-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-propyl]piperidin-4-yl-methyl ester

HRID 165730Notes

Reaction equation

HRID 165730 reaction equation
[C:32](=[O:33])([O-:34])[O-:35].[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[C:6](=[O:17])[CH2:7][CH2:8][c:9]2[cH:10][c:11]([F:16])[c:12]([F:15])[cH:13][c:14]21.[Cs+:36].[Cs+:37].[NH:18]1[CH2:19][CH2:20][CH:21]([CH2:24][O:25][C:26]([C:27]([CH3:28])([CH3:29])[CH3:30])=[O:31])[CH2:22][CH2:23]1.[O:39]=[CH:40][N:41]([CH3:42])[CH3:43].[OH2:38]>>[CH2:2]([CH2:3][CH2:4][N:5]1[C:6](=[O:17])[CH2:7][CH2:8][c:9]2[cH:10][c:11]([F:16])[c:12]([F:15])[cH:13][c:14]21)[N:18]1[CH2:19][CH2:20][CH:21]([CH2:24][O:25][C:26]([C:27]([CH3:28])([CH3:29])[CH3:30])=[O:31])[CH2:22][CH2:23]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 179561691-(3-Chloropropyl)-6,7-difluoro-3,4-dihydro-1H-quinolin-2-oneHCID 689120142,2-Dimethylpropionic acid piperidin-4-ylmethyl ester

Product 1

HCID 689104932,2-Dimethylpropionic acid 1-[3-(6,7-difluoro-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-propyl]piperidin-4-yl-methyl ester

Sources & evidence

ORD record
ord-686cd7cf658d4ad4a063fbeacf1b989c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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