Paclitaxel → 10-deacetylbaccatin III

Participants

Reaction Steps

In contrast, the same procedure as described in Example II was run on 10 grams of starting material having the same taxol and 10-deacetyltaxol percentages. The reaction solvent used was dichloromethane (as was used in the Magris, et al. procedure). The 10-deacetylbaccatin III yield was only 24%, 90 mg (a lower yield resulted from larger amounts of material) as analyzed by TLC. there as 69 mg of 10-deacetyltaxol remaining; 47% of the 10-deacetyltaxol was converted. Based on TLC analysis, the reaction in dichloromethane was run for one hundred twenty hours versus seventy-two hours.

Provenance & Evidence