Sodium → 2-{[1-(4-Chlorophenyl)ethyl]sulfanyl}-1-oxo-1lambda~5~-pyridine

HRID 1657333Notes

Reaction equation

HRID 1657333 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](Cl)[CH3:9])=[CH:4][CH:3]=1.[SH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N+:13]=1[O-:18].[Na]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N+:13]=2[O-:18])[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 5360545SodiumHCID 109759991-chloro-4-(1-chloroethyl)benzeneHCID 178526253HCID 178526253, compound

Product 1

HCID 541332702-{[1-(4-Chlorophenyl)ethyl]sulfanyl}-1-oxo-1lambda~5~-pyridineYield 78%

Procedure

The intermediate 2(-1-[4-chlorophenyl]ethylthio)pyridine N-oxide was prepared from 1-(4-chlorophenyl)ethylchloride and 2-mercaptopyridine N-oxide, sodium salt by the procedure described in Example 2. Melting point 106° - 108°C. Structure confirmed by IR and NMR.

Sources & evidence

ORD record
ord-253a935dabd34fb39060dedb518c5a09
Source dataset
uspto-grants-1976_06
Patent number
US03960542

Reaction notes

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