Hydrochloric Acid → HCID 178426633, compound

Participants

Reaction Steps

Thiourea (76 g, 1.0 mole) was suspended in a solution of 120 g (1.2 moles) of acetylacetone in 2,500 ml of ethanol. The resulting suspension was mixed with 250 ml of concentrated hydrochloric acid, and then reacted under reflux for 2 hours. After completion of the reaction, the reaction liquid was cooled, whereby beautiful yellow needle-like crystals of 2-mercapto-4,6-dimethyl-pyrimidine hydrochloride were formed. The reaction liquid was allowed to stand for a day to deposit sufficiently the crystals, which were then recovered by filtration and dried to obtain 140 g of 2-mercapto-4,6-dimethyl-pyrimidine hydrochloride in yield of 80 %.

Provenance & Evidence