Hydrochloric Acid → HCID 178426633, compound

HRID 1657355Notes

Reaction equation

HRID 1657355 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[C:5]([CH2:8][C:9](=O)[CH3:10])(=O)[CH3:6].[ClH:12]>C(O)C>[ClH:12].[SH:3][C:2]1[N:4]=[C:9]([CH3:10])[CH:8]=[C:5]([CH3:6])[N:1]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31261AcetylacetoneHCID 2723790Thiourea

Product 1

HCID 178426633HCID 178426633, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Thiourea (76 g, 1.0 mole) was suspended in a solution of 120 g (1.2 moles) of acetylacetone in 2,500 ml of ethanol. The resulting suspension was mixed with 250 ml of concentrated hydrochloric acid, and then reacted under reflux for 2 hours. After completion of the reaction, the reaction liquid was cooled, whereby beautiful yellow needle-like crystals of 2-mercapto-4,6-dimethyl-pyrimidine hydrochloride were formed. The reaction liquid was allowed to stand for a day to deposit sufficiently the crystals, which were then recovered by filtration and dried to obtain 140 g of 2-mercapto-4,6-dimethyl-pyrimidine hydrochloride in yield of 80 %.

Workup

  1. customreacted
  2. temperatureunder reflux for 2 hours
  3. customAfter completion of the reaction
  4. customthe reaction liquid
  5. temperaturewas cooled

Sources & evidence

ORD record
ord-70c7c9ddee9d45e4970e7efc2e9f6e55
Source dataset
uspto-grants-1976_06
Patent number
US03960829

Reaction notes

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