Hydrochloric Acid → HCID 21533306, compound

HRID 1657379Notes

Reaction equation

HRID 1657379 reaction equation
[Cl:1][C:2]1[C:3]([S:14][CH:15]([CH3:17])[CH3:16])=[CH:4][C:5]2[S:10](=[O:12])(=[O:11])[NH:9]C=[N:7][C:6]=2[CH:13]=1.Cl>[OH-].[Na+]>[S:10]([C:5]1[CH:4]=[C:3]([S:14][CH:15]([CH3:16])[CH3:17])[C:2]([Cl:1])=[CH:13][C:6]=1[NH2:7])(=[O:11])(=[O:12])[NH2:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178460706HCID 178460706, compound

Product 1

HCID 21533306HCID 21533306, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

6-Chloro-7-isopropylthio-1,2,4-benzothiadiazine-1,1-dioxide (0.03 mole), prepared as described in Example 2, is dissolved in 10% aqueous sodium hydroxide (50 ml.) and heated on the steam bath for 1 hour. The solution is chilled, acidified with hydrochloric acid and the product upon recrystallization from a mixture of ethanol and water melts at 137°-138° C.

Workup

  1. temperatureheated on the steam bath for 1 hour
  2. temperatureThe solution is chilled
  3. customthe product upon recrystallization
  4. additionfrom a mixture of ethanol and water melts at 137°-138° C.

Sources & evidence

ORD record
ord-4f06499fe9b3438bb27bbbaf3300be14
Source dataset
uspto-grants-1976_06
Patent number
US03960854

Reaction notes

Loading…