反应详情

A mixture of 2-sulfamoyl-4-isopropylthio-5-chloroaniline (0.02 mole) and chloroacetyl chloride (0.022 mole) in dioxane (75 ml.) is heated under reflux for 24 hours. The solution then is concentrated to dryness in vacuo, the residue dissolved in ethanol (60 ml.) and heated under reflux with potassium acetate (0.022 mole) and water (10 ml.) for 2 hours. The alcohol is removed in vacuo and the solution then acidified with hydrochloric acid. The precipitated product is recrystallized from a mixture of methanol and water to provide 3-chloromethyl-6-chloro-7-isopropylthio-1,2,4-benzothiadiazine-1,1-dioxide, m.p. 248°-250° C.

1. temperatureis heated
2. temperatureunder reflux for 24 hours
3. concentrationThe solution then is concentrated to dryness in vacuo
4. dissolutionthe residue dissolved in ethanol (60 ml.)
5. temperatureheated
6. customThe alcohol is removed in vacuo
7. customThe precipitated product is recrystallized from a mixture of methanol and water