HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Chlorophenyl)piperazine → 3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
| Reactant | 3-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one | HCID 4625408 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one | HCID 12414808 | 34.8% |
Reaction Steps
A mixture of 2.4 g of 3-(2-chloroethyl)-2,6-dimethy-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed with heating for 30 hours. The reaction mixture was then treated in the same manner as in Example 1, and the obtained crude crystals were recrystallized from isopropyl alcohol to give 1.4 g of the desired compound as pale yellow needles, m.p. 116.5° - 117.5°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03960863 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-cacede88fdc148cc8f70e8a89c0ca45c |
| Source note | uspto-grants-1976_06 |