Hydrochloric Acid → HCID 131710265, compound

Participants

Reaction Steps

A mixture of 2.5 g of 3-(2-chloroethyl)-2,6,8-trimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 5.3 g of 1-(m-tolyl)piperazine and 20 ml of toluene was refluxed for 24 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by means of column chromatography using alumina. The oil obtained from the eluate was converted into the hydrochloride, which was then recrystallized from ethanol to give 0.8 g of the desired compound as pale yellow powders, m.p. 274°C (decomp.).

Provenance & Evidence