Hydrochloric Acid → HCID 131710265, compound

HRID 1657406Notes

Reaction equation

HRID 1657406 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[C:11]([CH3:16])=[CH:12][C:13]([CH3:15])=[CH:14][C:7]2=[N:6][C:5]=1[CH3:17].[C:18]1([CH3:30])[CH:23]=[CH:22][CH:21]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:19]=1.[ClH:31]>C1(C)C=CC=CC=1>[ClH:1].[ClH:31].[C:18]1([CH3:30])[CH:23]=[CH:22][CH:21]=[C:20]([N:24]2[CH2:25][CH2:26][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[C:11]([CH3:16])=[CH:12][C:13]([CH3:15])=[CH:14][C:7]4=[N:6][C:5]=3[CH3:17])[CH2:28][CH2:29]2)[CH:19]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 831111-(m-Tolyl)piperazineHCID 12414938HCID 12414938, compound

Product 1

HCID 131710265HCID 131710265, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 2.5 g of 3-(2-chloroethyl)-2,6,8-trimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 5.3 g of 1-(m-tolyl)piperazine and 20 ml of toluene was refluxed for 24 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by means of column chromatography using alumina. The oil obtained from the eluate was converted into the hydrochloride, which was then recrystallized from ethanol to give 0.8 g of the desired compound as pale yellow powders, m.p. 274°C (decomp.).

Workup

  1. temperaturewas refluxed for 24 hours
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customthe obtained residue was purified by means of column chromatography
  5. customThe oil obtained from the eluate
  6. customwas then recrystallized from ethanol

Sources & evidence

ORD record
ord-f41bc109c1c64a01bbf58918703a7c89
Source dataset
uspto-grants-1976_06
Patent number
US03960863

Reaction notes

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