反应详情

温度

0 °C

4-Amino-6,7-dimethoxy-2-(7-nitro-1,2,3,4-tetrahydroisoquinolin-2-yl)quinazoline (2.0 g.), the product of Example 12, was slurried in 6N hydrochloric acid solution (100 ml.) and the resulting mixture was cooled with stirring to 0°C. A solution of stannous chloride (20.0 g.) in 6N hydrochloric acid (20 ml.) was then added, and the reaction mixture was heated gradually to 70°C., followed by cooling to give a white solid precipitate. The latter material was collected by means of suction filtration and thereafter recrystallized from ethanol to afford 1.0 g. of pure final product as the dihydrochloride dihydrate, m.p. 265°-266°C.

1. temperaturethe resulting mixture was cooled
2. temperaturethe reaction mixture was heated gradually to 70°C.
3. temperatureby cooling
4. customto give a white solid precipitate
5. filtrationThe latter material was collected by means of suction filtration
6. customrecrystallized from ethanol
7. customto afford 1.0 g