N-Hydroxysuccinimide → HCID 68147076, compound

HRID 1657421Notes

Reaction equation

HRID 1657421 reaction equation
[NH2:1][CH:2]1[C:20](=[O:21])[N:4]2[C:5]([C:17]([OH:19])=[O:18])=[C:6]([CH2:9][S:10][C:11]3[S:15][C:14]([CH3:16])=[N:13][N:12]=3)[CH2:7][S:8][C@H:3]12.[NH2:22][S:23]([CH2:26][C:27](O)=[O:28])(=[O:25])=[O:24].ON1C(=O)CCC1=O>>[NH2:22][S:23]([CH2:26][C:27]([NH:1][CH:2]1[C:20](=[O:21])[N:4]2[C:5]([C:17]([OH:19])=[O:18])=[C:6]([CH2:9][S:10][C:11]3[S:15][C:14]([CH3:16])=[N:13][N:12]=3)[CH2:7][S:8][C@H:3]12)=[O:28])(=[O:25])=[O:24]

Participants

4

Reactant 3

HCID 80170N-HydroxysuccinimideHCID 1108396117551-00-7HCID 129420347-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid

Product 1

HCID 68147076HCID 68147076, compound

Procedure

Using the procedure of Example 3, 7-amino-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4carboxylic acid is reacted with N-hydroxysuccinimidyl aminosulfonylacetate (prepared in a similar manner as set forth in Example 1 from aminosulfonylacetic acid and N-hydroxysuccinimide) to give the desired product.

Workup

  1. customprepared in a similar manner

Sources & evidence

ORD record
ord-8763c8faafb943b58890928b428c097a
Source dataset
uspto-grants-1976_06
Patent number
US03960852

Reaction notes

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