Hypochlorite → HCID 178524702, compound

HRID 1657452Notes

Reaction equation

HRID 1657452 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[OH:14])=[CH:11][CH:10]=[C:9]([CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[CH:8]=2)(=[O:3])C.Cl[O-:22]>O1CCOCC1>[CH:15]1([C:9]2[CH:8]=[C:7]3[C:12]([C:13]([OH:14])=[C:4]([C:1]([OH:22])=[O:3])[CH:5]=[N:6]3)=[CH:11][CH:10]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 61739HypochloriteHCID 178467063HCID 178467063, compound

Product 1

HCID 178524702HCID 178524702, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

10 g of powdered 3-acetyl-4-hydroxy-7-cyclohexylquinoline are added to a solution of 10 ml of dioxane and 10 g of a freshly prepared hypochlorite solution at room temperature. After 45 minutes, the unconverted acetyl compound is washed out with chloroform. The aqueous solution is acidified with 10% strength hydrochloric acid. The product which precipitates is washed with water and then dried. 7-Cyclohexyl-4-hydroxy-quinoline-3-carboxylic acid of melting point 241°-43°C is obtained.

Workup

  1. washthe unconverted acetyl compound is washed out with chloroform
  2. customThe product which precipitates
  3. washis washed with water
  4. customdried

Sources & evidence

ORD record
ord-7b75053f44be42a48145c33de0423093
Source dataset
uspto-grants-1976_06
Patent number
US03960868

Reaction notes

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