Thiourea → HCID 21533401, compound

HRID 1657454Notes

Reaction equation

HRID 1657454 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[C:5]([C:10]1[CH:11]=[N:12][C:13]2[C:18]([C:19]=1[Cl:20])=[CH:17][C:16]([CH:21]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)=[CH:15][CH:14]=2)([O:7][CH2:8][CH3:9])=[O:6]>CO.C(O)C>[ClH:20].[C:5]([C:10]1[CH:11]=[N:12][C:13]2[C:18]([C:19]=1[S:3][C:2](=[NH:4])[NH2:1])=[CH:17][C:16]([CH:21]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)=[CH:15][CH:14]=2)([O:7][CH2:8][CH3:9])=[O:6]

Participants

5

Reactant 2

HCID 2723790ThioureaHCID 21533367HCID 21533367, compound

Product 1

HCID 21533401HCID 21533401, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

A solution of 6.3 g of thiourea in 300 ml of methanol is added to a solution of 25 g of 3-carboethoxy-4-chloro-6-cycloheptyl-quinoline in 200 ml of ethanol and the mixture is left to stand for 2 days at room temperature. The crude 3-carboethoxy-4-amidinothio-6-cycloheptyl-quinoline-hydrochloride formed, of melting point 280°C (decomposition), is then filtered off.

Workup

  1. waitthe mixture is left

Sources & evidence

ORD record
ord-35b62f56ab834386ae87cfba4945cdf4
Source dataset
uspto-grants-1976_06
Patent number
US03960868

Reaction notes

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