Imidazole → 3-Chloro-1-imidazol-1-yl-4-phenylisoquinoline

HRID 1657582Notes

Reaction equation

HRID 1657582 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:4]([Cl:18])[N:3]=1.[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1>CN(C)C=O>[Cl:18][C:4]1[N:3]=[C:2]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:11]2[C:6]([C:5]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[CH:7][CH:8]=[CH:9][CH:10]=2

Participants

4

Reactant 2

HCID 795ImidazoleHCID 21534896HCID 21534896, compound

Product 1

HCID 1939953-Chloro-1-imidazol-1-yl-4-phenylisoquinoline

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.74 g (10 mmoles) of 1,3-dichloro-4-phenylisoquinoline abd 2.04 g (30 mmoles) of imidazole were heated for 3 hours to 150° C in 5 ml of dimethyl-formamide. Working up was effected as described uner 1d.

Sources & evidence

ORD record
ord-081a1b64196343b6ae015ac9e2c05307
Source dataset
uspto-grants-1976_06
Patent number
US03961062

Reaction notes

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