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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1657589Generated: October 25, 2026

1-Bromo-3-chloropropane → 2-Methoxy-6-dimethylsulphamoyl-10-(3-chloropropyl)phenothiazine

https://huagongshe.com/reaction/1657589

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-3-chloropropaneHCID 8006—
ReactantPotassium HydroxideHCID 14797—
Reactant2-Methoxy-6-dimethylsulphamoylphenothiazineHCID 21534844—
SolventMethyl Ethyl KetoneHCID 6569—
Product2-Methoxy-6-dimethylsulphamoyl-10-(3-chloropropyl)phenothiazineHCID 2153485760.4%

Reaction Steps

2-Methoxy-6-dimethylsulphamoyl-10-(3-chloropropyl)phenothiazine (m.p. 124°-126°C.; 62.6 g.) is prepared by reacting 1-bromo-3-chloropropane (147 g.) with 2-methoxy-6-dimethylsulphamoylphenothiazine (84.4 g.) in the presence of powdered potassium hydroxide (25.8 g.) in methyl ethyl ketone (300 cc.).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03961055
Source datasetuspto-grants-1976_06
ORD IDord-d7e3dbb01b2e4eb8b2ed179958e8bf84
Source noteuspto-grants-1976_06