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HRID1657590

反应详情

EQUATION

反应方程式

HRID 1657590 的结构方程式

REACTANTS

反应物

3
结构：COS(=O)(=O)OC
HCID6497

Dimethyl sulfate

C2H6O4S

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CN(C)S(=O)(=O)c1cccc2c1Sc1ccc(O)cc1N2
HCID21534833

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2c(c1)Nc1cccc(S(=O)(=O)N(C)C)c1S2
HCID21534844

未命名化合物

收率 45.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCC(C)=O
溶剂HCID6569

Methyl ethyl ketone

C4H8O

PROCEDURE

实验过程

2-Methoxy-6-dimethylsulphamoylphenothiazine (m.p. 196°-198°C.; 79.6 g.) is prepared by methylation, using dimethyl sulphate (74.5 g.), of 2-hydroxy-6-dimethylsulphamoylphenothiazine (168 g.) in the presence of powdered sodium hydroxide (30.8 g.) suspended in methyl ethyl ketone (1,820 cc.).