化工社化工社 化学情報印刷レポート · 研究参考用
1-Bromo-3-chloropropane → 2-Benzyloxy-6-dimethylsulphamoyl-10-(3-chloro-propyl)phenothiazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Benzyloxy-6-dimethylsulphamoylphenothiazine | HCID 21534823 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 2-Benzyloxy-6-dimethylsulphamoyl-10-(3-chloro-propyl)phenothiazine | HCID 21534843 | 108.8% |
反応手順
2-Benzyloxy-6-dimethylsulphamoyl-10-(3-chloro-propyl)phenothiazine (m.p. 124°-126°C.; 89.0 g.) is prepared by reacting 1-bromo-3-chloropropane (92 g.) with 2-benzyloxy-6-dimethylsulphamoylphenothiazine (69.0 g.) in the presence of powdered potassium hydroxide (16.4 g.) in methyl ethyl ketone (230 cc.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03961055 |
| 出典データセット | uspto-grants-1976_06 |
| ORD ID | ord-831e125b74ac454aa74af19e9671e971 |
| 出典メモ | uspto-grants-1976_06 |