Ammonia → HCID 53654624, compound

HRID 1657694Notes

Reaction equation

HRID 1657694 reaction equation
[C:1]1([CH:7]2[N:11]([CH2:12][CH2:13]O)[N:10]=[C:9]3[C:15](=[CH:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:16][S:17][CH2:18][CH:8]23)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)(C1C=CC(C)=CC=1)(=O)=O.S(C1C=CC(C)=CC=1)([O-])(=O)=O.[NH3:48]>N1C=CC=CC=1.C(O)C.O>[C:1]1([CH:7]2[N:11]([CH2:12][CH2:13][NH2:48])[N:10]=[C:9]3[C:15](=[CH:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:16][S:17][CH2:18][CH:8]23)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

8

Reactant 4

HCID 222AmmoniaHCID 73974-Toluenesulfonyl chlorideHCID 85570p-ToluenesulfonateHCID 53745416HCID 53745416, compound

Product 1

HCID 53654624HCID 53654624, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

3a,4,6,7-Tetrahydro-3-phenyl-7-(phenylmethylene)thiopyrano[4,3-c]pyrazole-2(3H)-ethanol is suspended in pyridine and treated with one equivalent of tosyl chloride. After standing at room temperature for about 16 hours, the mixture is poured into water and the tosylate is dissolved in ethanol, cooled and saturated with ammonia gas. After standing for 3 days, the excess ammonia and solvent are removed by evaporation to give the title compound.

Workup

  1. waitAfter standing for 3 days
  2. customthe excess ammonia and solvent are removed by evaporation

Sources & evidence

ORD record
ord-6b20ac1263fa4b04b05648cb610c0d23
Source dataset
uspto-grants-1976_06
Patent number
US03962222

Reaction notes

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