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HRID1657738

反应详情

EQUATION

反应方程式

HRID 1657738 的结构方程式

REACTANTS

反应物

2
结构：ClP(Cl)Cl
HCID24387

Phosphorous trichloride

Cl3P

结构：O=C(COc1ccccc1)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(Cl)CS[C@H]12
HCID67655752

未命名化合物

PRODUCTS

生成物

1
结构：O=C(COc1ccccc1)NC1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12
HCID6347548

未命名化合物

PROCEDURE

实验过程

Following the chlorination procedure of Example 19 p-nitrobenzyl 7-phenoxyacetamido-3-chloro-3-cephem-4-carboxylate was prepared with phosphorus trichloride. The p-nitrobenzyl ester group was removed by the acidic hydrogenolysis procedure described by Example 18 to provide the 3-chlorocephalosporanic acid antibiotic compound.

WORKUP

后处理

  1. customThe p-nitrobenzyl ester group was removed by the acidic hydrogenolysis procedure
  2. customto provide the 3-chlorocephalosporanic acid antibiotic compound