2-Furancarbonyl chloride → trans-1-(3-Phenylpropyl)-2,5-dimethyl-4-(2-furoyl)-piperazine hydrochloride

HRID 1657757Notes

Reaction equation

HRID 1657757 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([Cl:8])=[O:7].[C:9]1([CH2:15][CH2:16][CH2:17][N:18]2[CH2:23][C@@H:22]([CH3:24])[NH:21][CH2:20][C@@H:19]2[CH3:25])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C1C=CC=CC=1>[ClH:8].[C:9]1([CH2:15][CH2:16][CH2:17][N:18]2[CH2:23][C@@H:22]([CH3:24])[N:21]([C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)=[O:7])[CH2:20][C@@H:19]2[CH3:25])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 682422-Furancarbonyl chlorideHCID 44361659trans-1-(3-Phenylpropyl)-2,5-dimethylpiperazine

Product 1

HCID 68131090trans-1-(3-Phenylpropyl)-2,5-dimethyl-4-(2-furoyl)-piperazine hydrochloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2-Furoyl chloride (13 g) was added dropwise to a solution of trans-1-(3-phenylpropyl)-2,5-dimethylpiperazine [b.p. 138 - 140 (4 mmHg), dipicrate, m.p. 258° - 261°C] (21 g) and benzene (200 ml).

Sources & evidence

ORD record
ord-13a227e3794f4171aa5ad848fac7edc1
Source dataset
uspto-grants-1976_06
Patent number
US03962249

Reaction notes

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