Phosphorus oxychloride → HCID 22754264, compound

HRID 1657794Notes

Reaction equation

HRID 1657794 reaction equation
[Cl:1][C:2]1[C:15]2[O:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:16][CH:17]1[NH:21][C:20](=O)[CH2:19][CH2:18]1.P(Cl)(Cl)(Cl)=O>>[Cl:1][C:2]1[C:15]2[O:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]([C:20]3[CH2:19][CH2:18][CH:17]([CH3:16])[N:21]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 660555-Methyl-2-pyrrolidoneHCID 143402424-Chloro-10H-phenoxazine

Product 1

HCID 22754264HCID 22754264, compound

Procedure

Reaction of 4-chlorophenoxazine, 5-methyl 2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 4-CHLORO-10-(5-METHYL-1-PYRROLIN-2-YL)PHENOXAZINE, m.p. 120°-122°C., from ethanol. Conversion of the free base to the hydrochloride salt affords 4-CHLORO-10-(5-METHYL-1-PYRROLIN-2-YL)PHENOXAZINE HYDROCHLORIDE, m.p. 228°-230°C., (dec.) (corr.), by trituration with hot benzene.

Sources & evidence

ORD record
ord-ab50c78cebb74493be0121906f910add
Source dataset
uspto-grants-1976_06
Patent number
US03962252

Reaction notes

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