Benzyl chloroformate → HCID 21530318, compound

HRID 1657804Notes

Reaction equation

HRID 1657804 reaction equation
[CH3:1][C:2]([CH3:12])([CH2:4][NH:5][C:6](=[O:11])[CH2:7][CH:8]([CH3:10])[CH3:9])[NH2:3].[CH2:13]([O:20][C:21](Cl)=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1C=CC=CC=1>[CH2:13]([O:20][C:21]([N:5]1[C:6](=[O:11])[CH2:7][C:8]([CH3:9])([CH3:10])[NH:3][C:2]([CH3:1])([CH3:12])[CH2:4]1)=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 10387Benzyl chloroformateHCID 21530342HCID 21530342, compound

Product 1

HCID 21530318HCID 21530318, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 17 parts of 2,2,7,7-tetramethyl-1,4-diazaheptan-5-one, 19 parts of benzylchloroformate and 250 parts of dry benzene was heated at reflux for 16 hours. The solvent was then evaporated in vacuo to yield an almost colourless oil. Addition of 20 parts of petroleum ether (of boiling range 40° to 60°C) produced 4-benzyloxycarbonyl-2,2,7,7-tetramethyl-1,4-diazacycloheptan-5-one as a colourless solid of melting point 86° -88°C. This material gave the following elemental analysis by weight:

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. customThe solvent was then evaporated in vacuo
  4. customto yield an almost colourless oil

Sources & evidence

ORD record
ord-01bdee11b9584802b05f66b2fc3a6344
Source dataset
uspto-grants-1976_06
Patent number
US03962255

Reaction notes

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