Allyl bromide → 1'-allyl-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one

Participants

Reaction Steps

A mixture of 1.02 g. of 1,3-dihydrospiro[isobenzofuran-1,4'-piperidine]-3-one, 1.0 g. of sodium bicarbonate, 10 ml. of chloroform, and 0.60 g. of allyl bromide is stirred at room temperature for 24 hours and filtered. The filtrate is washed with water, dried over potassium carbonate, and concentrated to an oily solid.

Provenance & Evidence