HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Chloro1,3-dihydro-1'-methylspiro[isobenzofuran-1,4'-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(4-Chloro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine | HCID 86733528 | — |
| Product | 6-Chloro1,3-dihydro-1'-methylspiro[isobenzofuran-1,4'-piperidine] | HCID 21506825 | — |
Reaction Steps
Treatment of 4-(4-chloro-α-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine with hydrochloric acid by the method described in Example 16d provides 6-chloro-1,3-dihydro-1'-methylspiro[isobenzofuran-1,4'-piperidine].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03962259 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-56726de3b1d946928c6889960264b828 |
| Source note | uspto-grants-1976_06 |